Therapeutic drug monitoring
What is therapeutic drug monitoring?
Therapeutic drug monitoring is an area of clinical chemistry that specialises in measuring medication levels (concentrations) in patients, usually through blood samples but also through saliva samples. Because anti-epileptic drugs are among the types of drugs that can be easily under dosed or over dosed, they are particularly suitable for monitoring. The measured levels are used by the doctor to adjust each patient’s individual dosage and schedule to each patient’s individual therapeutic requirement. Thus, drug efficacy (the anti-epileptic effect of a drug) is kept to a maximum while the undesirable side effects are kept to a minimum.
Monitoring antiepileptic drugs
There are now 19 anti-epileptic drugs licensed for the management of patients with epilepsy in the UK and up to a further five new drugs can be expected to be licensed within the next four to five years. During the past 10-20 years therapeutic monitoring of anti-epileptic drugs has served to substantially enhance the management of patients with epilepsy because drug administration (prescriptions) can be individualised.
Epilepsy Society’s Therapeutic Drug Monitoring Unit (TDM)
We provide a therapeutic drug monitoring (TDM) assay service for antiepileptic drugs (AEDs) and a pharmacokinetic consultation service (looking at how drugs distribute in the blood over time) to help individualise patient drug therapy. We carry out detailed pharmacokinetic investigation of individual patients who have experienced an unusual clinical response to drugs during therapy or following overdose.
The Unit is accredited by Clinical Pathology Accreditation (CPA) UK Ltd and equipped with state-of-the-art automated analytical equipment. We provide a specialist AED analytical service to the National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, and to many hospitals and organisation throughout the UK and from Europe.
How can the service be accessed?
The service can be accessed by referral from a GP, neurologist or other healthcare professional. For more information contact:
Professor P N Patsalos, Therapeutic Drug Monitoring Unit (TDM), Epilepsy Society, Chalfont St Peter, Chesham Lane, Buckinghamshire, SL9 0RJ, UK. Email: TDM_Unit@epilepsysociety.org.uk