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26 February 2016

Study reveals optimal dose for anti-seizure drug lamotrigine

Researchers have found the optimal dose for lamotrigine, a commonly-prescribed drug used in the treatment of epilepsy.

Scientists from Tel Aviv University and the Hebrew University of Jerusalem examined the best dosage option for lamotrigine when used on its own in the treatment of adults with complex partial seizures, with or without secondarily generalised seizures.

The study, published in the medical journal Brain and Behavior, evaluated the records of 188 ‘eligible’ people who had been treated with lamotrigine between 2011 and 2014.  The cases were analysed for a range of information, including dosage levels, treatment efficacy, side effects and retention rates.

Of the study participants, 77 per cent were found to have continued their lamotrigine treatment, and the average effective dose was found to be 250 mg or higher. Benefits of taking the drug were more pronounced in subjects over the age of 30 years, and in those who had lived with their epilepsy for five or more years.

The researchers concluded that it may be appropriate to reach a daily lamotrigine dose above 250 mg in adults experiencing epilepsy for more than five years, using lamotrigine as an individual therapy.