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levetiracetam

Generic name: Levetiracetam

Available as: Desitrend: granules 250mg, 500mg, 1000mg.
Keppra: tablets 250mg, 500mg, 750mg, 1000mg, oral solution 100mg/ml.
​Levetiracetam: tablets 250mg, 500mg, 750mg, 1000mg, oral solution 100mg/ml.

Adults

Average total daily dose: Up to 1500mg twice daily.

Doses per day: 2

Treatment: Monotherapy and add-on therapy for focal seizures with or without secondary generalisation. Add-on therapy for myoclonic seizures in Juvenile Myoclonic Epilepsy.

Most common possible side effects include the following. Report severe reactions, such as a skin rash, to your doctor.
Anorexia, weight changes, abdominal pain, nausea, vomiting, diarrhoea, drowsiness, unsteadiness, dizziness, headache, tremor, amnesia, aggression, agitation, depression, anxiety, and double or blurred vision.

Children

Average total daily dose: 1 – 6 months: up to 21mg/kg twice daily. 6 months and over: up to 30mg/kg twice daily (if body weight under 50kg). From 12 years: up to 1500mg twice daily (if body weight over 50kg).

Doses per day: 2

Treatment: Add-on therapy for focal, myoclonic and tonic clonic seizures.

Most common possible side effects include the following. Report severe reactions, such as a skin rash, to your doctor. 
Nausea, vomiting, diarrhoea, abdominal pain, anorexia, weight changes, dizziness, drowsiness and behaviour change.
 

 

Please note:

  • This information is a guide only, and lists the usual daily doses of anti-epileptic drugs (AEDs). The dose taken may be different to those listed above.

  • Treatment of neonatal seizures (from birth to 28 days of age) is not covered.

  • Most doses are listed as ‘mg/kg’: this means milligrams of AED per kg of the child’s weight.

  • Children starting AED treatment at the age of 12 may start on adult doses. Some AEDs are only used for children aged 12 and over (including eslicarbazepine acetate, lacosamide, perampanel, pregabalin, retigabine and tiagabine).

  • Some AED doses are listed as ‘twice daily’ (for example ‘5mg/kg twice daily’). This means that the dose listed is taken each time (and so the total daily dose will be double that listed).

  • Some AED doses are listed as ‘divided into 2 (or 3) doses’ (for example ‘25 - 30mg/kg daily divided into 2 doses’). This means that the total amount listed is divided into two to give the dose taken each time.

  • ‘Effective’ means the seizures it works for. ‘Monotherapy’ means the AED is taken on its own. ‘Add-on therapy’ means the AED is taken alongside other AEDs. ‘Tolerance’ means that a drug becomes less effective the longer you take it.

  • Information for this page comes from sources including the British National Formulary (BNF), the British National Formulary for children (BNFC) and the electronic medicines Compendium (eMC). The side effects listed here are some of the most common possible side effects and may be worded differently in the patient information leaflet for the AED. Doctors may refer to the BNF/BNFC for starting doses and how to increase doses. For more details, and a complete list of side effects, visit medicines.org.uk/emc(opens new window).

  • Every effort is made to ensure that all information is correct at time of publishing but information may change after publication. This information is not a substitute for advice from your doctor. Epilepsy Society is not responsible for any actions taken as a result of using this information.