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TDM unit

The Therapeutic Drug Monitoring Unit (TDM Unit), based at the Chalfont Centre for Epilepsy, and equipped with the latest analytical equipment (LC/MS), provides a comprehensive TDM assay service for antiepileptic drugs (AEDs) and a pharmacokinetic consultation service as an aid to individualizing patient drug therapy.

The Unit will undertake the detailed pharmacokinetic investigation of individual patients with unusual clinical response to drugs during therapy or following overdose. Presently, it is the only AED TDM service in the UK which provides an analytical service for 24 AEDs currently licensed for clinical use and 2 pharmacologically active metabolites.

The Unit provides a specialist AED TDM service for in-patients and out-patients attending the National Hospital for Neurology and Neurosurgery (Queen Square), University College Hospitals NHS Trust and Epilepsy Society. Also, sample referrals are received from many NHS and private hospitals, institutions, forensic laboratories, private pathology laboratories and from veterinary practices throughout the UK. The service provision is cost effective and with rapid turnaround times.

Read our user's guide to therapeutic monitoring of antiepileptic drugs.

The Unit is accredited by United Kingdom Accreditation Service (UKAS) in accordance with the recognised International Standard ISO 15189:2012 for Medical Laboratories – requirements for quality and competence. Registration number is 8353 (https://search.ukas.com/#/tabbed/search?q=national%20society%20for%20Epilepsy&ati=1).