what is therapeutic drug monitoring?
Therapeutic drug monitoring (TDM) is an area of clinical chemistry that specialises in measuring medication levels (concentrations) in patients, usually through blood samples but also through saliva samples. Because anti-epileptic drugs are among the types of drugs that can be easily under dosed or over dosed, they are particularly suitable for monitoring. The measured levels are used by the doctor to adjust each patient’s individual dosage and schedule to each patient’s individual therapeutic requirement. Thus, drug efficacy (the anti-epileptic effect of a drug) is kept to a maximum while the undesirable side effects are kept to a minimum.
Monitoring antiepileptic drugs
There are now 27 anti-epileptic drugs (AEDs) licensed for the management of patients with epilepsy in the UK. We offer a TDM service for 24 of these drugs and 2 pharmacologically active metabolites. During the past 10-20 years therapeutic monitoring of anti-epileptic drugs has served to substantially enhance the management of patients with epilepsy because drug administration (prescriptions) can be individualised.
Epilepsy Society’s Therapeutic Drug Monitoring Unit (TDM)
We provide a TDM assay service for AEDs and a pharmacokinetic consultation service (looking at how drugs distribute in the blood over time) to help individualise patient drug therapy. We carry out detailed pharmacokinetic investigation of individual patients who have experienced an unusual clinical response to drugs during therapy or following overdose.
We provide a specialist AED analytical service to the National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, and to many hospitals and organisation
throughout the UK and from Europe.
NB: The Unit has voluntarily suspended its accreditation to ISO 15189:2012, pending review of its Quality Management System (QMS), installation of a new eQMS and recruiting staff to some unfilled vacancies.
How can the service be accessed?
The service can be accessed by referral from a GP, neurologist or other healthcare professional. For more information contact:
Epilepsy Society Chalfont Centre switchboard number: 01494 601300,
Patient results and enquiries: 01494 601 423
Main laboratory: 01494 601 424
Consultant Clinical Scientist & Head of Unit, Dr K Kipper: 01494 601 423
Transformation Advisor, Mr F McQueen: 01494 601 355
Quality & Administration Manager, Ms C Choinkowska: 01494 601 490
Clinical Scientist, Mr A W James: 01494 601 494
Clinical Scientist, Mr F P Quinlivan: 01494 601 424
Consultant Clinical Scientist (part-time), Dr E P Spencer