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research projects

Understanding how an individual's genetic make-up can affect their risk of developing epilepsy, the consequences and their response to treatment is central to research at Epilepsy Society Research Centre. Through our research projects, we hope to unravel the complex genetic architecture of the epilepsies and bring new hope for people with the condition.

Pioneering brain imaging is also enabling more people to achieve seizure freedom through epilepsy surgery. Our research has shown that those who become seizure free enjoy better employment prospects and a better quality of life.

21 Years of MRI

Professor John Duncan explains the difference that MRI has made to the diagnosis and treatment of epilepsy over 21 years, and how it has helped to change lives.

Brain and Tissue Bank

The Epilepsy Society Brain and Tissue Bank is  dedicated to the study of epilepsy and is a collaborative project between Epilepsy Society and University College London (UCL) and is based at the UCL Institute of Neurology. 

SUDEP (Sudden Unexpected Death in Epilepsy)

Our research team is trying to identify genes that may increase the risk of sudden unexpected death in epilepsy (SUDEP) in some individuals.

Ketogenic diet

The ketogenic diet is a high fat, low carbohydrate, protein controlled diet. We are trying to establish why some children with uncontrolled epilepsy respond to it while others don't. 

Individualised treatment

A key outcome for our research is to find the right drug at the right dosage for each individual from the point of diagnosis. Using a specific blood test - an array Comparative Genomic Hybridisation (aCGH) test - we hope to narrow down the field of genes that might cause epilepsy. 

Optical coherence tomography

Optical Coherence Tomography - one of the most advanced optical scanning tools - is being used to measure peripheral vision and the thickness of the retinal fibres at the back of the eye.

Cortical excitability in epilepsy

This study is using a new technique - Transcranial Magnetic Stimulation(TMS) - to study brain excitability in people with epilepsy.

3D face imaging

We know that the shape of the human face is influenced by genetic factors. Now our researchers are using 3D imaging, or three-dimensional stereophotogrammetry,  to establish whether there is a link between face shape and genetic variations which can lead to epilepsy. 

Brain imaging for surgery

Many people with focal epilepsy continue to have seizures despite medication. Surgery may offer a cure, but MRI scans are completely normal in about 30 per cent of patients. 

Epilepsy navigator

We have created the prototype of a sophisticated form of 'smart surgery' - the Epilepsy Navigator - which we hope will help us  identify critical areas of brain structure and function, and improve the precision and accuracy of surgery. 

EpiPGX project

Researchers at Epilepsy Society are working alongside renowned scientists from across Europe to identify genetic characteristics that could help to ensure people with epilepsy are given the right medication, at the right dose, at the point of diagnosis.

DOORS syndrome - the genetic basis

A new study, led by our researchers, has unlocked the genetic cause of DOORS syndrome - a rare condition characterised by disabilities including deafness, intellectual impairment and seizures.